93 research outputs found

    Review of juxtaglomerular cell tumor with focus on pathobiological aspect

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    Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases

    A NEW COMPUTER PROGRAM FOR THE ANALYSIS AND FITTING OF SINGLET- TRIPLET SPECTRA OF ORTHORHOMBIC ASYMMETRIC TOP MOLECULES IN THE PROLATE OR OBLATE LIMITS

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    Author Institution: Department of Chemistry, University of Wisconsin-Parkside, Kenosha, WI 53141The original version of our singlet-triplet rotational least-squares/band contour analysis program } has been modified to run under Microsoft Windows using the C++ programming language. The new version takes full advantage of the graphical capabilities of the Microsoft Foundation Class. Specifically, windows can be created that edit the input file, summarize the results of the least-squares fit, display the calculated and observed spectra, display whole or partial sections of the calculated spectrum as a stick or Gaussian de-convoluted spectrum. A listing of the rotational quantum numbers in the case (a) and case (b) limits for each of the displayed lines is provided. A branch annotating routine provides a quick visual guide to the assignment of the spectrum. A new eigenvalue sorting method has been added as an option that complements the existing method based on the eigenvector coefficients. The new sorting method has eliminated some difficulties that may arise using the existing "Least Ambiguous Method". The program has been extended to handle near- oblate asymmetric tops using a type IIIr^{r} representation. The talk will also focus on some of the problems that can arise when spin-spin and spin-rotation constants are refined within an inappropriate representation

    Expression of thyroid transcription factor 1 in primary brain tumours

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    Background: Thyroid transcription factor 1 (TTF-1) is expressed in a proportion of carcinomas derived from follicular thyroid cells and respiratory epithelium. Immunohistochemical detection of this protein was shown previously to be a helpful aid in tumour diagnosis, specifically in deciding whether a tumour is primary to the lung/thyroid gland or metastatic. Recently, TTF-1 expression was also observed in certain areas of postnatal brain. Aim/Method: To investigate the expression of TTF-1 protein in a spectrum of 73 primary brain tumours including astrocytomas, glioblastomas, ependymomas, oligodendrogliomas, medulloblastomas, and gangliogliomas of different sites. Results: All the tumours were negative for TTF-1 except for two ependymomas of the third ventricle. Conclusions: The expression of TTF-1 in brain tumours appears to be site specific rather than associated with tumour dedifferentiation. The presented expression of TTF-1 protein in certain primary brain tumours should be taken into consideration when interpreting the immunohistochemical staining of brain tumours of uncertain primary site

    Effect of Temperature and Photoperiod on the Biology of Blue Alfalfa Aphid, Acyrthosiphon kondoi Shinji

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    The developmental and reproductive biology of the blue alfalfa aphid, Acyrthosiphon kondoi Shinji, was studied under 15 temperature/photoperiod regimes. Five temperatures (10°,15°,20°,25°, 30°C) and three photophases (8, 12,16 h per 24 h) were utilized in controlled environmental chambers. Temperature played the most significant role in the development and reproduction of the aphid. Optimum temperatures for development ranged from 20° to 25°, and the upper survival temperature ranged from 25° to 30°, depending upon the photoperiod. The lethal temperature was 30°. Higher survival and total fecundity occurred at low temperatures (10° to 15°) rather than at high temperatures (20° to 25°). There were significant temperature by photoperiod interactions on the rates of nymphal development, fecundity, longevity, and generation time. The changes in these rates were most prevalent at low temperatures. Shorter generation and doubling times, and a greater intrinsic rate of increase by A. kondoi, may account for the early dominance of this species over A. pisum in the spring in the U.S. alfalfa fields
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